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Flights from McGhee Tyson Airport to San Diego Intl. Airport Cheap Flights from Knoxville to San Diego Prices were available within the past 7 days and starts at 79 for one-way flights and for round. Search for San Diego flights on KAYAK now to find the best deal. Cheap Flights from Knoxville to San Diego from 84 - KAYAK Fly from Knoxville on Frontier, American Airlines, Alaska Airlines and more.

Compare & reserve one-way or return flights from Knoxville to San Diego from only to get the best flight deals and promotions for your TYS to MYF trip!

Pilot great at communicating, good snacks.

Find United Airlines cheap flights from Knoxville to San Diego. Enjoy a Knoxville to San Diego modern flight experience in premium cabins with Wi-Fi.

There are no direct flights from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.). But we can direct you to airlines which offer flights with only one stopover.

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